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Single Protein Behavior Observed in Unprecedented Detail
Scrutinizing a single molecule for more than a few milliseconds used to require effectively "stapling" it down, inhibiting its normal behavior. Now, using a newly developed technique chemists have for the first time confined a protein (one involved in photosynthesis), observed its behavior for more than a second and learned things about it that could influence solar energy technology and biofuels ...continue
Society for Biomolecular Sciences and Association for Laboratory Automation Propose Merger
For the past 18 months, the Society for Biomolecular Sciences and the Association for Laboratory Automation have been strategizing a merger to unite their complementary missions within the context of one inclusive organization — the Society for Laboratory Automation and Screening ...continue
King Cobra Venom Promises Drug Discovery Insights
The King Cobra continues to weave its charm with researchers identifying a protein in its venom with the potential for new drug discovery and for advancing understanding of disease mechanisms. The novel protein, named haditoxin, was discovered in Manjunatha Kini’s laboratory at the National University of Singapore ...continue
Stem Cell Fate: New method decodes movements, predicts how cells will divide
Researchers have discovered a new method for predicting, with up to 99 percent accuracy, the fate of stem cells. Using advanced computer vision technology to detect subtle cell movements that are impossible to discern with the human eye, they can successfully forecast how a stem cell will split and what key characteristics the daughter cells will exhibit ...continue
Studying Protein Folding, Dynamics in Living Cells
A new technique to study protein dynamics in living cells has been created by a team of scientists, and evidence yielded from the new method indicates that an in vivo environment strongly modulates a protein’s stability and folding rate ...continue
PANGAEA Earth System Research Data Directly Linked to Elsevier Articles
Elsevier has announced that the data library PANGAEA — Publishing Network for Geoscientific & Environmental Data — and Elsevier have implemented reciprocal linking between their respective content in earth system research. Research data sets deposited at PANGAEA are now automatically linked to the corresponding articles in Elsevier journals on its electronic platform ScienceDirect and vice versa ...continue
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ARTICLES
Thinking Beyond ELN
A look at the informatics architecture model 
Michael H. Elliott 
Over the course of the last three years, electronic laboratory notebook (ELN) products have expanded their core capabilities to include functionality not envisaged in the early days of the “paper replacement” ELN. With the introduction of LIMS-like features, such as structured data management, request management, reporting, task workflow automation and new application modules, ELN is offering benefits across a wide range of laboratory types
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Validation Update: State of the Art 2009
Lack of documentation, system validation reflect all too common uncertainty 
Sandy Weinberg, Ph.D. and Ron Fuqua, Ph.D. 
The United States Food and Drug Administration has promulgated standards for the testing and management control of computer systems used in clinical testing, manufacturing execution systems (MES), laboratory information management systems (LIMS), computerized medical devices and other systems since 1985. This year is the fifth anniversary of the most recent formalization of those requirements, found in 21 CFR Part 11
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Animal Stories: Justifying LIMS is a vicious and cruel task
Those who best articulate benefits stand a chance, even in thin-budget times 
Randy C. Hice 
Animal stories make my day in the Denver Post each morning. The latest involved a lady walking to her car in Evergreen who was attacked in a parking lot by an elk. Now, elk are like deer on anabolic steroids, and there’s no joy in getting on their bad side
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Take Me Out to the Ball Game: Three regulatory scenarios
If rules directly impact on life and death, wouldn’t you prefer an independent Umpire?
web exclusive
Sandy Weinberg, Ph.D., and Ron Fuqua, Ph.D.
Take Me Out to the Ball Game: Three regulatory scenariosThere are three major pharmaceutical regulatory scenarios operating in different parts of the globe. If an organization is trying, with all good intentions, to conform to the regulatory requirements for a laboratory information management system (or any other aspect of regulated operations) understanding which scenario is in play is an excellent first step
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A New Snowboard will not Save Me
Why meet and greet conferences don’t pay off
web exclusive
Randy C. Hice
A New Snowboard will not Save MeSnowboarding has a much higher learning curve than skiing, largely due to the asymmetry of the techniques involved to successfully aim a small flat missile down a steep mountain, with your feet locked into bindings that do not release
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10 Product Selection Tips
Gloria Metrick
Stop! Read this list before making your next software purchase
The tips that follow are designed to help you select your next informatics product or other software you may plan to purchase
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MULTIMEDIA AND EVENTS
Implementing a Successful Knowledge Management Solution
How to pull it all together to achieve a simple user experience
Suzanne Tracy, Editor in Chief
From drug discovery through approval and monitoring life cycles, a successful knowledge management solution can go a long way toward helping to achieve business goals. But how do you pull it all together to implement a successful platform? Recently, a panel of experts provided guidance on overcoming many of the common challenges — both technological and cultural — that are often associated with implementing a knowledge management solution. Discussion highlights
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PRODUCTS
Nova-LIMS
Nova-LIMS is an out-of-the-box Laboratory Information Management software solution that can be tailored to meet specific customer requirements. This client/server product is a process-driven solution that is 21 CFR Part 11 compliant and enforces current and good manufacturing practices ...continue
Omega 11
Omega 11 laboratory software provides a comprehensive tool that handles all phases of laboratory operations, from quotation to final report and invoice ...continue
Matrix Express
Matrix Express offers a low cost entry level LIMS suitable for the smaller laboratory or single department within a larger organization. Matrix Express provides all of the key functions expected of a LIMS ...continue
Instrument Control Framework
The Instrument Control Framework (ICF), is a software component making it faster and easier for third-party software to enable and control liquid chromatography systems in chromatographic data systems or workstations ...continue
LabWare ELN
LabWare ELN provides scientists and other laboratory personnel with the automation tools necessary to manage experiments, properly execute tasks and capture, preserve and safeguard intellectual property ...continue
VersaLIMS.NET
This modular self-contained Laboratory Data Management System is designed to deliver the level of data management required by small to medium sized labs. The VersaLIMS.NET base system includes a PC, barcode reader, barcode printer and the core VersaLIMS.NET software ...continue
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